As the pandemic continues to linger and disrupt, enterprises are settling into a new operational model that has work-from-anywhere as its core driver. Employees and their technology will continue to work in either a fully remote, or at best a hybrid IT model. And this is in addition to other disruptive constants like migration to the Cloud, or expanding use of IoT. The scope of managing IT infrastructure is becoming both broader and deeper, while still remaining mission-critical. The breadth of requirements can lead to analysis paralysis, which can often be mitigated by a relatively short and focused list of what we have found to be best practices.